Buzzing Through the Blood-Brain Barrier

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Prof. Thanh Nguyen’s research group has reported on the first biodegradable ultrasonic transducer that can help medication move from blood vessels into brain tissues and circumvent the body’s traditional defense mechanisms.The work is published in the journal of PNAS (Proceeding of National Academy of Science) (Dec 2019), and the two first authors of this paper are PhD students in Nguyen lab, namely Thinh Le and Eli Curry.

A PLLA piezoelectric nanofiber film (left) to generate an acoustic wave (middle) that can open the blood-brain barrier (BBB) (right) to deliver medicines into the brain tissue.

When implanted into the brain, this novel device can generate ultrasonic waves for buzzing drugs through the blood-brain barrier (BBB) to treat brain diseases (e.g. cancers), and then self-vanish, avoiding the need of invasive removal surgery that is often required for conventional medical implants. More details can be found in the UConn Today article.