Faculty News

New Models Help Predict Protein Dynamic Signatures

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This breakthrough in accurately predicting protein crystallization propensity is vital for developing drugs and understanding diseases

A new computational model and tool developed at UConn uses advanced techniques to analyze protein dynamics and predict their crystallization propensity accurately. (Christopher LaRosa/UConn Photo)

To the average person, knowing how a protein wiggles might not seem that exciting or pertinent, but then again, most people aren’t fascinated by the natural movements and fluctuations of proteins and their functional properties. If, however, you were interested in designing new drugs, better understanding how diseases can be eradicated or enhancing biotechnology for industrial and therapeutic applications, you might be on the edge of your seat waiting to see what a new study on protein sequencing and crystallization has to offer.

An article about that study, authored by Anna Tarakanova, assistant professor in the School of Mechanical, Aerospace, and Manufacturing Engineering at UConn’s College of Engineering, has just appeared in a prominent monthly scientific journal, Matter, which focuses on the general field of materials science. The study examines how the natural movements and fluctuations of proteins – the protein’s “wiggles” – can help predict their functional properties. Tarakanova was assisted by Mohammad Madani, a Mechanical Engineering graduate student and first author of the study.

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Dr. Stephanie Santos, an MAM alumna, named to the Vergnano Endowed Chair for Inclusion

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Stephany Santos, named to the newly established Vergnano Endowed Chair for Inclusion, sees her role as helping students build successful engineering futures, no matter the challenges

Professor Stephany Santos at the Vergnano Showcase in April 2024. (Matthew Hodgkins/UConn Photo)

Stephany Santos, the new Vergnano Endowed Chair for Inclusion at UConn’s College of Engineering, feels like she’s been preparing for this role since she set foot on UConn’s campus in 2008, as an undergraduate preparing to study mechanical engineering.

Prior to her first summer at UConn, she was a participant in the BRIDGE program, which is a transitionary preparation program designed to support the success of incoming first-year students that are underrepresented in engineering.

The BRIDGE program, then run out of the Engineering Diversity Program led by Kevin McLaughlin, became a hallmark of her identity and purpose as an engineering student and leader at UConn, says Santos ’12 (ENG) ’20 Ph.D. She volunteered for every program offered by the Engineering Diversity Program, from Multiply Your Options, a program designed to inspire 8th-grade girls to think about STEM, to the Northeast Regional Science Bowl, the largest regional competition in the country for high school students competing quiz-bowl-style in STEM questions.

During this period Santos also helped found UConn’s student organization Engineering Ambassadors. This is an organization that supports K-12 teachers and education systems by broadening understanding and access to engineering, and by exploring how engineers can change the world for good. These programs, Santos explains, are foundational in creating confidence academically, connections psychosocially and inspiration professionally.

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Mission Complete: Lee Spends 45 Days in NASA Simulated Journey to Mars

by Olivia Drake – UConn College of Engineering

By participating in the mission, College of Engineering’s Jason Lee contributed to NASA’s efforts to study how future astronauts may react to isolation and confinement during deep-space journey.

College of Engineering Associate Professor-in-Residence Jason Lee, pictured third from left, recently participated in a 45-day simulated space mission at the Johnson Space Center in Houston, Texas. Also pictured are his crew mates, Piyumi Wijesekara, Shareef Al Romaithi, and Stephanie Navarro. (James Blair/NASA)

Jason Lee’s lifelong aspiration to explore outer space became a reality—without ever needing to leave planet Earth.

For 45 days, Lee, associate professor-in-residence in the School of Mechanical, Aerospace, and Manufacturing Engineering, lived in NASA’s Human Exploration Research Analog (HERA) habitat at Johnson Space Center, participating in a simulated journey to Mars.

There, he and three other crew members operated in a constrained environment, completing mission-critical tasks, conducting repairs, viewing Martian landscapes through virtual reality, and making communication attempts with Mission Control.

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Professor Jiong Tang receives the ASME Myklestad Award

Jiong TangProfessor Jiong Tang, a distinguished figure in the field of mechanical engineering, has recently been honored with the prestigious ASME Myklestad Award in 2024. This award, established by the American Society of Mechanical Engineers (ASME), recognizes individuals who have made significant contributions to vibration engineering, particularly in areas related to analytical methods, experimental approaches, and practical applications in mechanical and aerospace systems. Prof. Tang’s work exemplifies the high standards of innovation, rigor, and impact that the Myklestad Award celebrates, showcasing his commitment to advancing the field of vibration engineering through both fundamental research and practical advancements.

Throughout his career, Prof. Tang has led pioneering research that has transformed understanding and approaches within dynamics and vibration. His contributions span a broad array of applications, including structural health monitoring, smart materials, and robust control systems. His research has not only pushed theoretical boundaries but also driven technological advancements that enhance the resilience, functionality, and safety of mechanical systems in various industries. His work has been particularly influential in aerospace and civil engineering, where precise vibration control is critical for ensuring the structural integrity and performance of complex systems.

This honor not only acknowledges his past accomplishments but also underscores his ongoing contributions to the advancement of engineering knowledge and practice.

Prof. Pierce Elected Fellow of the ASME

David PierceProf. David Pierce has been elected as a Fellow of the American Society of Mechanical Engineers (ASME), one of the highest honors awarded by the organization. This prestigious recognition celebrates Dr. Pierce’s significant contributions to the field of mechanical engineering, acknowledging years of dedicated research, innovative teaching, and impactful advancements within the discipline. As a Fellow, Prof. Pierce joins an elite group of professionals who have demonstrated exceptional achievements and leadership in mechanical engineering, further enhancing the visibility and impact of their work on a global scale.

Prof. Norato Elected Fellow of the ASME

 

Prof. Julián Norato has been honored as a Fellow of the American Society of Mechanical Engineers (ASME). The Fellow grade of membership recognizes exceptional engineering achievements and contributions to the engineering profession and to ASME. The recognition was announced at the ASME International Design Engineering Technical Conferences held in Washington D.C. in August, 2024.

Prof. Nguyen receives multiple large grants from the NIH and the Gates Foundation

by Matt Engelhardt

Through millions in coveted grants, the National Institutes of Health (NIH) and the Bill and Melinda Gates Foundation are recognizing how impactful Thanh Nguyen’s research is to the field of biomedical engineering.

Nguyen, an associate professor of mechanical engineering and biomedical engineering, has already established himself as one of the top-funded researchers at UConn. The NIH is adding to that success by awarding Nguyen four R01 grants totaling more than $9.5 million, with $7.5 million going to UConn researchers.

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Fourth Annual Women in STEM Conference Gains Traction

Panelists Ran Feng, Kristina Wagstrom, and Zongjie Wang during the Women in STEM Frontiers in Research Expo

Women in the science, technology, engineering, and mathematics fields are experiencing a new period of growth, acceptance, and respect in the modern workforce.

But when UConn alumna Jeanine Armstrong Gouin studied civil engineering in the 1980s, it was hard to feel welcome in an engineering building that didn’t even have a women’s bathroom.

Despite the dreary beginning, Gouin (who graduated in 1987, about four years before the Castleman Building installed women’s restrooms) delivered an inspirational message to an audience of young female STEM students last week.

The Women in STEM Frontiers in Research Expo (WiSFiRE) was held on Friday at the UConn Storrs campus. It brought together university undergraduate and graduate students, faculty, staff, alumni, and STEM employees and supporters.

WiSFiRE was one of the first conferences in the region to specifically highlight the work of women researchers in STEM. That mission has been solidified through a recent endowment by Gouin.

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Xu Receives the ASME Young Investigator Award

professor hong yi xu

Dr. Xu received the 2024 ASME Design Automation Young Investigator Award in recognition of his research at the intersection of Microstructure Material Design, design for Additive Manufacturing, Design of Mixed Stochasticity Structural Systems, and Uncertainty Quantification.

This award is presented annually to honor an exceptional young investigator making significant contributions in design automation, with a focus on areas such as design representation, optimization, evaluation, and integration. The award was given at the ASME Design Automation Conference, held from August 25-28, 2024, in Washington, DC. The conference gathers international experts in the field of design automation each year.